The unfolded protein response is required for dendrite morphogenesis

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چکیده

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The unfolded protein response is required for dendrite morphogenesis

Precise patterning of dendritic fields is essential for the formation and function of neuronal circuits. During development, dendrites acquire their morphology by exuberant branching. How neurons cope with the increased load of protein production required for this rapid growth is poorly understood. Here we show that the physiological unfolded protein response (UPR) is induced in the highly bran...

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The Unfolded Protein Response is Required for Dendrite Morphogenesis 1

13 Precise patterning of dendritic fields is essential for the formation and function of 14 neuronal circuits. During development, dendrites acquire their morphology by 15 exuberant branching. How neurons cope with the increased load of protein 16 production required for this rapid growth is poorly understood. Here we show that 17 the physiological unfolded protein response (UPR) is induced in ...

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ژورنال

عنوان ژورنال: eLife

سال: 2015

ISSN: 2050-084X

DOI: 10.7554/elife.06963